NPR1 Protein (Myc-DYKDDDDK Tag)
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- Target See all NPR1 Proteins
- NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NPR1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human NPR1 / ANPRA protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NPR1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
- Alternative Name
- Npr1,anpra (NPR1 Products)
- Synonyms
- ANPRA Protein, ANPa Protein, GUC2A Protein, GUCY2A Protein, NPRA Protein, Anpra Protein, Gca Protein, NPR-A Protein, Npra Protein, sGC Protein, si:dkey-27c15.1 Protein, AI893888 Protein, GC-A Protein, Pndr Protein, ARABIDOPSIS NONEXPRESSER OF PR GENES 1 Protein, ATNPR1 Protein, F15H21.6 Protein, F15H21_6 Protein, NIM1 Protein, NON-INDUCIBLE IMMUNITY 1 Protein, NONEXPRESSER OF PR GENES 1 Protein, REGULATORY PROTEIN NPR1 Protein, SAI1 Protein, SALICYLIC ACID INSENSITIVE 1 Protein, natriuretic peptide receptor 1 Protein, natriuretic peptide receptor 1a Protein, regulatory protein (NPR1) Protein, NPR1 Protein, Npr1 Protein, npr1a Protein
- Background
- Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2 MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
- Molecular Weight
- 118.7 kDa
- NCBI Accession
- NP_000897
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