PITX2 Protein (His tag)

Catalog No. ABIN2729028

Product Details

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PITX2 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human PITX2 (full length, N-term HIS tag, transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Alternative Name: Pitx2 (PITX2 Products)

Synonyms: ARP1 Protein, Brx1 Protein, IDG2 Protein, IGDS Protein, IGDS2 Protein, IHG2 Protein, IRID2 Protein, Otlx2 Protein, PTX2 Protein, RGS Protein, RIEG Protein, RIEG1 Protein, RS Protein, 9430085M16Rik Protein, Brx1a Protein, Brx1b Protein, Munc30 Protein, Pitx2a Protein, Pitx2b Protein, Pitx2c Protein, Pitx2cbeta Protein, Ptx2 Protein, Rieg Protein, pitx2a Protein, pitx2c Protein, zgc:110508 Protein, XPtx2b Protein, xPtx2 Protein, xpitx2 Protein, arp1 Protein, brx1 Protein, idg2 Protein, igds Protein, igds2 Protein, ihg2 Protein, irid2 Protein, otlx2 Protein, pitx2-A Protein, ptx2 Protein, rgs Protein, rieg Protein, rieg1 Protein, pitx-2 Protein, pitx2 Protein, paired like homeodomain 2 Protein, paired-like homeodomain transcription factor 2 Protein, paired-like homeodomain 2 Protein, paired like homeodomain 2 S homeolog Protein, paired like homeodomain 2 L homeolog Protein, PITX2 Protein, Pitx2 Protein, pitx2 Protein, pitx2.S Protein, pitx2.L Protein

Background: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Molecular Weight: 30.2 kDa

NCBI Accession: NP_700476

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development