TCF3 Protein (His tag)
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- Target See all TCF3 Proteins
- TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TCF3 protein is labelled with His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human TCF3 / E2A (N-term HIS tag, transcript variant 1) protein expressed in E.coli.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product TCF3 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the N-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
- Alternative Name
- Tcf3,e2a (TCF3 Products)
- Synonyms
- E2A Protein, E47 Protein, ITF1 Protein, TCF-3 Protein, VDIR Protein, bHLHb21 Protein, tcf3a Protein, zgc:113045 Protein, A1 Protein, AA408400 Protein, ALF2 Protein, AW209082 Protein, E12 Protein, E12/E47 Protein, ME2 Protein, Pan1 Protein, Pan2 Protein, Tcfe2a Protein, bhlhb21 Protein, e2a Protein, itf1 Protein, tcfe2a Protein, vdir Protein, xtcf-3 Protein, xtcf3 Protein, G12 Protein, TCF7L1 Protein, XE3 Protein, transcription factor 3 Protein, transcription factor 3b Protein, transcription factor 3 L homeolog Protein, transcription factor E2a Protein, TCF3 Protein, tcf3b Protein, Tcf3 Protein, tcf3.L Protein, tcfe2a Protein
- Background
- This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(119), with PBX1), childhood leukemia (t(1919), with TFPT) and acute leukemia (t(1219), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
- Molecular Weight
- 67.4 kDa
- NCBI Accession
- NP_003191
- Pathways
- WNT Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response
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