USP20 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
-
- Target See all USP20 Proteins
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
- Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This USP20 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human USP20 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product USP20 Protein
-
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Alternative Name
- Usp20 (USP20 Products)
- Synonyms
- USP20 Protein, vdu2 Protein, lsfr3a Protein, LSFR3A Protein, VDU2 Protein, hVDU2 Protein, 1700055M05Rik Protein, AI467231 Protein, Vdu2 Protein, im:7151955 Protein, zgc:63661 Protein, universal stress protein Protein, ubiquitin specific peptidase 20 Protein, ubiquitin specific peptidase 20 L homeolog Protein, RR_RS15875 Protein, USP20 Protein, usp20 Protein, Usp20 Protein, usp20.L Protein
- Background
- This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
- Molecular Weight
- 101.7 kDa
- NCBI Accession
- NP_006667
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
-