USP20 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2735100

Product Details

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This USP20 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human USP20 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Alternative Name: Usp20 (USP20 Products)

Synonyms: USP20 Protein, vdu2 Protein, lsfr3a Protein, LSFR3A Protein, VDU2 Protein, hVDU2 Protein, 1700055M05Rik Protein, AI467231 Protein, Vdu2 Protein, im:7151955 Protein, zgc:63661 Protein, universal stress protein Protein, ubiquitin specific peptidase 20 Protein, ubiquitin specific peptidase 20 L homeolog Protein, RR_RS15875 Protein, USP20 Protein, usp20 Protein, Usp20 Protein, usp20.L Protein

Background: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.

Molecular Weight: 101.7 kDa

NCBI Accession: NP_006667

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling