FNDC5 Protein (AA 29-149, Extracellular Domain)
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- Target See all FNDC5 Proteins
- FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))
- Protein Type
- Recombinant
- Protein Characteristics
- Extracellular Domain, AA 29-149
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Origin
- Human, Mouse, Rat
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Characteristics
- FNDC5 (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100 % identity between human, mouse and rat.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product FNDC5 Protein
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Fibronectin Type III Domain Containing 5 (FNDC5) (AA 1-137) protein (GST tag)
FNDC5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 32-143) protein (His-IF2DI Tag)FNDC5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 15-127) protein (His tag)FNDC5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 14-78) protein (GST tag)FNDC5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibronectin Type III Domain Containing 5 (FNDC5) protein (His tag)FNDC5 Origin: Human, Mouse, Rat Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 32-152) protein (His tag)Crystallography grade FNDC5 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 29-149) protein (His tag)Crystallography grade FNDC5 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 32-143) protein (rho-1D4 tag)Crystallography grade FNDC5 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 32-212) protein (rho-1D4 tag)Crystallography grade FNDC5 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Fibronectin Type III Domain Containing 5 (FNDC5) (AA 29-140) protein (rho-1D4 tag)Crystallography grade FNDC5 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))
- Alternative Name
- FNDC5 (FNDC5 Products)
- Synonyms
- FRCP2 Protein, irisin Protein, 1500001L03Rik Protein, AI836596 Protein, C87088 Protein, PeP Protein, Pxp Protein, fndc5 Protein, si:dkey-264p5.1 Protein, zgc:158684 Protein, fibronectin type III domain containing 5 Protein, fibronectin type III domain containing 5b Protein, FNDC5 Protein, Fndc5 Protein, fndc5b Protein
- Background
- Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
- Molecular Weight
- ~16kDa
- UniProt
- Q8NAU1
- Pathways
- Hormone Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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