Neuregulin 4 Protein (NRG4) (AA 2-62) (His tag)
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- Target See all Neuregulin 4 (NRG4) Proteins
- Neuregulin 4 (NRG4)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-62
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Neuregulin 4 protein is labelled with His tag.
- Sequence
- AA 2-62
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 8.6 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NRG4 Protein
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Neuregulin 4 (NRG4) (AA 1-115) protein (GST tag)
NRG4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neuregulin 4 (NRG4) (AA 1-61) protein (His tag)NRG4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Neuregulin 4 (NRG4) (Active) proteinNRG4 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- Neuregulin 4 (NRG4)
- Alternative Name
- Neuregulin-4 (NRG4 Products)
- Synonyms
- HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein
- Background
- Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
- Molecular Weight
- 8.6 kDa
- UniProt
- Q8WWG1
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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