MINPP1 Protein (AA 31-487) (His tag)

Catalog No. ABIN4370405

Product Details

Target: MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1 (MINPP1))

Protein Type: Recombinant

Protein Characteristics: AA 31-487

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This MINPP1 protein is labelled with His tag.

Purpose: Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 (C-6His)

Sequence: SLLEPRDPVA SSLSPYFGTK TRYEDVNPVL LSGPEAPWRD PELLEGTCTP VQLVALIRHG TRYPTVKQIR KLRQLHGLLQ ARGSRDGGAS STGSRDLGAA LADWPLWYAD WMDGQLVEKG RQDMRQLALR LASLFPALFS RENYGRLRLI TSSKHRCMDS SAAFLQGLWQ HYHPGLPPPD VADMEFGPPT VNDKLMRFFD HCEKFLTEVE KNATALYHVE AFKTGPEMQN ILKKVAATLQ VPVNDLNADL IQVAFFTCSF DLAIKGVKSP WCDVFDIDDA KVLEYLNDLK QYWKRGYGYT INSRSSCTLF QDIFQHLDKA VEQKQRSQPI SSPVILQFGH AETLLPLLSL MGYFKDKEPL TAYNYKKQMH RKFRSGLIVP YASNLIFVLY HCENAKTPKE QFRVQMLLNE KVLPLAYSQE TVSFYEDLKN HYKDILQSCQ TSEECELARA NSTSDELVDH HHHHH

Characteristics: Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 produced by transfected human cellss is a secreted protein with sequence (Ser31-Leu487) of Human MINPP1 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 10 % Glycerol, pH 7.5.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1 (MINPP1))

Alternative Name: mipp (MINPP1 Products)

Synonyms: HIPER1 Protein, MINPP2 Protein, MIPP Protein, AA408516 Protein, minpp1 Protein, zgc:56080 Protein, zgc:76991 Protein, zgc:153026 Protein, multiple inositol-polyphosphate phosphatase 1 Protein, multiple inositol polyphosphate histidine phosphatase 1 Protein, multiple inositol-polyphosphate phosphatase 1b Protein, multiple inositol-polyphosphate phosphatase 1a Protein, MINPP1 Protein, Minpp1 Protein, minpp1b Protein, minpp1a Protein

Sub Type: Fusionprotein

Background: Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). MINPP1 may play a role in bone development (endochondral ossification).
Alternative Names: Multiple Inositol Polyphosphate Phosphatase 1, 2,3-Bisphosphoglycerate 3-Phosphatase, 2,3-BPG Phosphatase, Inositol (1,3,4,5)-Tetrakisphosphate 3-Phosphatase, Ins(1,3,4,5)P(4) 3-Phosphatase, MINPP1, MIPP

Molecular Weight: 53.14 kDa

UniProt: Q9UNW1