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SNCA Protein (full length)

Name: SNCA Protein (full length)
Brand: antibodies-online
SKU: ABIN5065824
Price: 615 USD
Availability: InStock

Recombinant SNCA protein expressed in Escherichia coli (E. coli).

SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Aggregate (Control) . (SNCA Protein (full length))

SDS

Evaluation of a-syn toxicity on primary mouse cortical neurons. (SNCA Protein (full length))

Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers . (SNCA Protein (full length))

Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 µg/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 µg/ml (A-C). (SNCA Protein (full length))

IF/ICC

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5065824) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5065824). (SNCA Protein (full length))

Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Pre-formed Fibrils (ABIN5065824) at 4 μg/mL (D-F), but not when treated with Type 2 Alpha Synuclein Pre-formed Fibrils (ABIN5065824) at 4 μg/mL (A-C). (SNCA Protein (full length))

Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) (Catalog No. (SNCA Protein (full length))

TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065824) (SNCA Protein (full length))

8 images

Catalog No. ABIN5065824

Datasheet as PDF

Quick Overview for SNCA Protein (full length) (ABIN5065824)

Target

See all SNCA Proteins

SNCA (Synuclein, alpha (SNCA))

Protein Type

Recombinant

Biological Activity

Active

Origin

Human

Source

Escherichia coli (E. coli)

Application

SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)

Purity

92% pure using SDS-PAGE analysis.

Discover our top product SNCA Protein

Protein Characteristics

full length

Sequence

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

Specificity

~14.46 kDa

Purification

Ion-exchange Purified

Biological Activity Comment

Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.
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Expression System

Conjugate

Origin

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SNCA Protein (AA 1-140) (His tag)

Expression System HEK-293 Cells

Conjugate His tag

Origin Human

Price starts at $13,686.36

SNCA Protein (AA 1-140) (Strep Tag)

Expression System Cell-free protein synthesis (CFPS)

Conjugate Strep Tag

Origin Human

Price starts at $20,480.57

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Synuclein, alpha (SNCA) (A53T) (Active) protein
SNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

Synuclein, alpha (SNCA) (full length) (Active) protein
SNCA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

Synuclein, alpha (SNCA) (full length) (Active) protein
SNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant >95% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active

Synuclein, alpha (SNCA) (AA 1-140) protein (His tag)
custom-made SNCA Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Synuclein, alpha (SNCA) (AA 1-140) protein (His tag)
custom-made SNCA Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Synuclein, alpha (SNCA) protein
SNCA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE

Synuclein, alpha (SNCA) (AA 1-140) protein (His tag)
SNCA Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Synuclein, alpha (SNCA) (active) protein
SNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure SDS

Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag)
SNCA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag)
SNCA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

Application Notes

Optimal working dilution should be determined by the investigator.

Comment

Certified 92% pure using SDS-PAGE analysis.

Restrictions

For Research Use only
Concentration

Lot specific

Buffer

PBS pH 7.4

Storage

-80 °C
Target

SNCA (Synuclein, alpha (SNCA))

Alternative Name

Alpha Synuclein

Background

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Molecular Weight

14.46 kDa

Gene ID

6622

NCBI Accession

NP_000336

UniProt

P37840

Pathways

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity