nectin-3 Protein (partial) (His tag)
Quick Overview for nectin-3 Protein (partial) (His tag) (ABIN5608452)
Target
See all nectin-3 (NECTIN3) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- partial
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Purification tag / Conjugate
- This nectin-3 protein is labelled with His tag.
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Sequence
- Gly 58 - Asp 400
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Endotoxin Level
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
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Application Notes
- This recombinant protein can be used for WB.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
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Alternative Name
- Nectin-3
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Background
- Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
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Molecular Weight
- 39.6 kDa
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Gene ID
- 25945
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NCBI Accession
- NP_056295
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UniProt
- Q9NQS3
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Pathways
- Cell-Cell Junction Organization
Target
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