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nectin-3 Protein (partial) (His tag)

This Recombinant nectin-3 protein is produced in HEK-293 Cells.
Catalog No. ABIN5608452

Quick Overview for nectin-3 Protein (partial) (His tag) (ABIN5608452)

Target

See all nectin-3 (NECTIN3) Proteins
nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Protein Type

Recombinant

Origin

  • 16
  • 2
Human

Source

  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Application

Western Blotting (WB)

Purity

>95 % as determined by SDS-PAGE.
  • Protein Characteristics

    partial

    Purification tag / Conjugate

    This nectin-3 protein is labelled with His tag.

    Sequence

    Gly 58 - Asp 400

    Endotoxin Level

    Endotoxin level is less than 1.0 EU per ug by the LAL method.
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  • Application Notes

    This recombinant protein can be used for WB.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
  • Target

    nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

    Alternative Name

    Nectin-3

    Background

    Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

    Molecular Weight

    39.6 kDa

    Gene ID

    25945

    NCBI Accession

    NP_056295

    UniProt

    Q9NQS3

    Pathways

    Cell-Cell Junction Organization
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