Glutamate Receptor 3 Protein (AA 151-250, partial) (His-SUMO Tag)

Catalog No. ABIN5709613

Product Details

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Protein Type: Recombinant

Protein Characteristics: AA 151-250, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Glutamate Receptor 3 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: SLLGHYKWEK FVYLYDTERG FSILQAIMEA AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS RGYHYMLANL

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Alternative Name: GRIA3 (GRIA3 Products)

Synonyms: AMPA Protein, gria3 Protein, GRIN3A Protein, glur3b Protein, gria3.2 Protein, zfGRIA3[b] Protein, si:bz1o18.1 Protein, SI:zC231H1.1 Protein, si:zc140k5.3 Protein, GLUR3 Protein, GLUR-C Protein, GLUR3/C Protein, GRIA3 Protein, glur3 Protein, GluA3 Protein, GluR-3 Protein, GluR-C Protein, GluR-K3 Protein, GLUR-K3 Protein, GLURC Protein, MRX94 Protein, 2900064I19Rik Protein, Glur-3 Protein, Glur3 Protein, Gluralpha3 Protein, glutamate receptor, ionotropic, AMPA 3b Protein, glutamate ionotropic receptor AMPA type subunit 3 Protein, glutamate receptor, ionotropic, AMPA 3 Protein, glutamate receptor, ionotropic, AMPA 3 L homeolog Protein, glutamate receptor, ionotropic, AMPA3 (alpha 3) Protein, gria3b Protein, GRIA3 Protein, gria3 Protein, gria3.L Protein, Gria3 Protein

Background: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous syst and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous syst. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Molecular Weight: 27.97 kDa

UniProt: P42263

Pathways: PI3K-Akt Signaling, cAMP Metabolic Process, Synaptic Membrane