MMP2 Protein (AA 110-662) (His-SUMO Tag)
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- Target See all MMP2 Proteins
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 110-662
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Origin
- Rat
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MMP2 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- YNFFPRKPKW DKNQITYRII GYTPDLDPET VDDAFARALK VWSDVTPLRF SRIHDGEADI MINFGRWEHG DGYPFDGKDG LLAHAFAPGT GVGGDSHFDD DELWTLGEGQ VVRVKYGNAD GEYCKFPFLF NGREYSSCTD TGRSDGFLWC STTYNFEKDG KYGFCPHEAL FTMGGNGDGQ PCKFPFRFQG TSYNSCTTEG RTDGYRWCGT TEDYDRDKKY GFCPETAMST VGGNSEGAPC VFPFTFLGNK YESCTSAGRS DGKVWCATTT NYDDDRKWGF CPDQGYSLFL VAAHEFGHAM GLEHSQDPGA LMAPIYTYTK NFRLSNDDIK GIQELYGPSP DADTDTGTGP TPTLGPVTPE ICKQDIVFDG IAQIRGEIFF FKDRFIWRTV TPRDKPTGPL LVATFWPELP EKIDAVYEAP QEEKAVFFAG NEYWVYSAST LERGYPKPLT SLGLPPDVQQ VDAAFNWSKN KKTYIFSGDK FWRYNEVKKK MDPGFPKLIA DSWNAIPDNL DAVVDLQGGG HSYFFKGAYY LKLENQSLKS VKFGSIKSDW LGC
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product MMP2 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
- Alternative Name
- MMP2 (MMP2 Products)
- Synonyms
- 2-MMP Protein, CG1794 Protein, DM2-MMP Protein, Dm2-MMP Protein, Dmel\\CG1794 Protein, MMP2 Protein, anon-WO0118547.84 Protein, dm-2MMP Protein, dmmp2 Protein, l(2)02353 Protein, mmp2 Protein, wu:fa99h12 Protein, wu:fk89d01 Protein, fgmmp-2 Protein, Mmp-2 Protein, LOC100135793 Protein, Clg4a Protein, GelA Protein, MMP-2 Protein, CLG4 Protein, CLG4A Protein, MMP-II Protein, MONA Protein, TBE-1 Protein, matrix metallopeptidase 2 Protein, Matrix metalloproteinase 2 Protein, matrix metalloproteinase 2 Protein, matrix metalloproteinase-2 Protein, MMP2 Protein, Mmp2 Protein, mmp2 Protein, LOC657982 Protein, LOC100135793 Protein
- Background
- Ubiquitinous metalloproteinase that is involved in diverse functions such as rodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues .PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels .
- Molecular Weight
- 78.1 kDa
- UniProt
- P33436
- Pathways
- Activation of Innate immune Response
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