Neuregulin 2 Protein (NRG2) (AA 112-405) (His-SUMO Tag)

Catalog No. ABIN5710027

Product Details

Target: Neuregulin 2 (NRG2)

Protein Type: Recombinant

Protein Characteristics: AA 112-405

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Neuregulin 2 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: CYSPSLKSVQ DQAYKAPVVV EGKVQGLVPA GGSSSNSTRE PPASGRVALV KVLDKWPLRS GGLQREQVIS VGSCVPLERN QRYIFFLEPT EQPLVFKTAF APLDTNGKNL KKEVGKILCT DCATRPKLKK MKSQTGQVGE KQSLKCEAAA GNPQPSYRWF KDGKELNRSR DIRIKYGNGR KNSRLQFNKV KVEDAGEYVC EAENILGKDT VRGRLYVNSV STTLSSWSGH ARKCNETAKS YCVNGGVCYY IEGINQLSCK CPNGFFGQRC LEKLPLRLYM PDPKQKAEEL YQKR

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: Neuregulin 2 (NRG2)

Alternative Name: NRG2 (NRG2 Products)

Synonyms: NRG2 Protein, Don1 Protein, NTAK Protein, DON1 Protein, HRG2 Protein, NTAK_alpha2a Protein, Ntak Protein, neuregulin 2 Protein, NRG2 Protein, Nrg2 Protein

Background: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Molecular Weight: 48.76 kDa

UniProt: O14511

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway