RAB11A Protein (AA 2-213) (His-SUMO Tag)

Catalog No. ABIN5710201

Product Details

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Protein Type: Recombinant

Protein Characteristics: AA 2-213

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This RAB11A protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: GTRDDEYDYL FKVVLIGDSG VGKSNLLSRF TRNEFNLESK STIGVEFATR SIQVDGKTIK AQIWDTAGQE RYRAITSAYY RGAVGALLVY DIAKHLTYEN VERWLKELRD HADSNIVIML VGNKSDLRHL RAVPTDEARA FAEKNGLSFI ETSALDSTNV EAAFQTILTE IYRIVSQKQM SDRRENDMSP SNNVVPIHVP PTTENKPKVQ CC

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: RAB11A (RAB11A, Member RAS Oncogene Family (RAB11A))

Alternative Name: RB11A (RAB11A Products)

Synonyms: rab11 Protein, RAB11A Protein, wu:fi15h09 Protein, zgc:103679 Protein, yl8 Protein, Rab11a Protein, rab11A Protein, DDBDRAFT_0190819 Protein, DDBDRAFT_0191190 Protein, DDB_0190819 Protein, DDB_0191190 Protein, YL8 Protein, RAB11 Protein, RAB11A, member RAS oncogene family S homeolog Protein, RAB11A, member RAS oncogene family Protein, RAB11a, member RAS oncogene family Protein, Rab11 GTPase Protein, rab11A protein Protein, Rab11a, GTPase Protein, Rab GTPase Protein, rab11A, RAB family GTPase Protein, rab11a.S Protein, RAB11A Protein, rab11a Protein, Rab11a Protein, rab11A Protein

Background: The small GTPases Rab are key regulators of intracellular mbrane trafficking, from the formation of transport vesicles to their fusion with mbranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to mbranes different set of downstream effectors directly responsible for vesicle formation, movent, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of mbrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical mbrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma mbrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma mbrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma mbrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral mbranes. May also play a role in melanosome transport and release from melanocytes.

Molecular Weight: 39.89 kDa

UniProt: P62491

Pathways: Regulation of Cell Size, Thromboxane A2 Receptor Signaling, Regulation of long-term Neuronal Synaptic Plasticity