IFNK Protein (AA 24-195) (His tag)
IFNK
Origin: Cow
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Target See all IFNK products
- IFNK (Interferon, kappa (IFNK))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-195
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Origin
- Cow
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IFNK protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- CYLSEDHMLG ARENLRLLAR MNRLSPHPCL QDRKDFGLPQ EMVEGNQLQK DQAISVLHEM LQQCFNLFYT EHSSAAWNTT LLEQLCTGLQ QQLEDLDACL GPVMGEKDSD MGRMGPILTV KKYFQGIHVY LKEKEYSDCA WEIIRVEMMR ALSSSTTLQK RLRKMGGDLN SL
- Purification
- SDS-PAGE
- Purity
- > 90 %
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Interferon, kappa (IFNK) (AA 1-207) protein (GST tag)
IFNK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interferon, kappa (IFNK) (AA 35-129) protein (GST tag)IFNK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- IFNK (Interferon, kappa (IFNK))
- Alternative Name
- IFNT1 (IFNK Products)
- Synonyms
- IFNK Protein, IFNT1 Protein, INFE1 Protein, RP11-27J8.1 Protein, interferon kappa Protein, IFNK Protein, Ifnk Protein
- Background
- Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
- Molecular Weight
- 23.8 kDa
- UniProt
- P15696
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