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CSNK2A1/CK II alpha Protein (AA 8-350, partial) (His-SUMO Tag)

CSNK2A1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5711209
  • Target See all CSNK2A1/CK II alpha (CSNK2A1) Proteins
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 8-350, partial
    Origin
    • 8
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CSNK2A1/CK II alpha protein is labelled with His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    SRARVYAEVN SLRSREYWDY EAHVPSWGNQ DDYQLVRKLG RGKYSEVFEA INITNNERVV VKILKPVKKK KIKREVKILE NLRGGTNIIK LIDTVKDPVS KTPALVFEYI NNTDFKQLYQ ILTDFDIRFY MYELLKALDY CHSKGIMHRD VKPHNVMIDH QQKKLRLIDW GLAEFYHPAQ EYNVRVASRY FKGPELLVDY QMYDYSLDMW SLGCMLASMI FRREPFFHGQ DNYDQLVRIA KVLGTEELYG YLKKYHIDLD PHFNDILGQH SRKRWENFIH SENRHLVSPE ALDLLDKLLR YDHQQRLTAK EAMEHPYFYP VVKEQSQPCA DNAVLSSGLT AAR
    Purification
    SDS-PAGE
    Purity
    > 90 %
    Top Product
    Discover our top product CSNK2A1 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    Alternative Name
    CSK21 (CSNK2A1 Products)
    Synonyms
    CK2A2 Protein, CSNK2A1 Protein, CK2A1 Protein, CKII Protein, CSNK2A3 Protein, CK2A Protein, Ck2a Protein, BmCK2a Protein, wu:fi38e04 Protein, wu:fi38h03 Protein, csnk2a1 Protein, CK-II Protein, CK2 Protein, Ckiialpha Protein, Csnk2a1-rs4 Protein, ck2a1 Protein, casein kinase 2 alpha 2 Protein, casein kinase 2 alpha 1 Protein, casein kinase 2 alpha subunit Protein, casein kinase 2, alpha 1 polypeptide Protein, CK2 protein kinase alpha 2 Protein, casein kinase II alpha subunit Protein, Casein kinase II alpha subunit Protein, casein kinase 2, alpha 1 polypeptide S homeolog Protein, CSNK2A2 Protein, CSNK2A1 Protein, ck2a Protein, Ck2a Protein, csnk2a1 Protein, cka2 Protein, Ckiialpha Protein, CK2A1 Protein, Csnk2a1 Protein, csnk2a1.S Protein
    Background
    Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assbly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.
    Molecular Weight
    56.6 kDa
    UniProt
    P68400
    Pathways
    SARS-CoV-2 Protein Interactome
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