NPC2 Protein (AA 22-149) (His tag)
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- Target See all NPC2 Proteins
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-149
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Origin
- Dog
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NPC2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- VHFKDCGSAV GVIKELNVNP CPAQPCKLHK GQSYSVNVTF TSNIPSQSSK AVVHGIVLGV AVPFPIPEAD GCKSGINCPI QKDKTYSYLN KLPVKNEYPS IKLVVQWMLL GDNNQHLFCW EIPVQIEG
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product NPC2 Protein
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Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) protein (GST tag)
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Niemann-Pick Disease, Type C2 (NPC2) protein (His tag)NPC2 Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Niemann-Pick Disease, Type C2 (NPC2) (AA 20-151) protein (His tag)Crystallography grade NPC2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Niemann-Pick Disease, Type C2 (NPC2) (AA 20-149) protein (His tag)Crystallography grade NPC2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
Niemann-Pick Disease, Type C2 (NPC2) (AA 22-149), (full length) protein (His tag)NPC2 Origin: Dog Host: Yeast Recombinant > 90 % ELISA
Niemann-Pick Disease, Type C2 (NPC2) (AA 22-149) protein (His tag)NPC2 Origin: Dog Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
- Alternative Name
- NPC2 (NPC2 Products)
- Synonyms
- 2700012J19Rik Protein, AA408070 Protein, AU045843 Protein, HE1 Protein, EDDM1 Protein, re1 Protein, CE1 Protein, EPI-1 Protein, cb292 Protein, sb:cb292 Protein, NPC intracellular cholesterol transporter 2 Protein, Niemann-Pick disease, type C2 Protein, Npc2 Protein, NPC2 Protein, npc2 Protein
- Background
- Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting mbrane of late endosomes/ lysosomes to the ER and plasma mbrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport .
- Molecular Weight
- 18.1 kDa
- UniProt
- Q28895
- Pathways
- SARS-CoV-2 Protein Interactome
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