NR1H4 Protein (AA 1-476, Isoform 3) (His-SUMO Tag)
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- Target See all NR1H4 Proteins
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Protein Type
- Recombinant
- Protein Characteristics
- Isoform 3, AA 1-476
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NR1H4 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSKMNLIEH SHLPTTDEFS FSENLFGVLT EQVAGPLGQN LEVEPYSQYS NVQFPQVQPQ ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK KPRMGASAGR IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG RDLRQVTSTT KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI LTEMATNHVQ VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD LLEERIRNSG ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK LQEPLLDVLQ KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFTPLLC EIWDVQ
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product NR1H4 Protein
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Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 363-472) protein (GST tag)
NR1H4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476) protein (GST tag)NR1H4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-486) protein (Strep Tag)Crystallography grade NR1H4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-488) protein (Strep Tag)Crystallography grade NR1H4 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) proteinNR1H4 Origin: Rat Host: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA, IP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Alternative Name
- NR1H4 (NR1H4 Products)
- Synonyms
- zgc:110190 Protein, zgc:92742 Protein, NR1H4 Protein, BAR Protein, FXR Protein, HRR-1 Protein, HRR1 Protein, RIP14 Protein, AI957360 Protein, Fxr Protein, Rxrip14 Protein, nuclear receptor subfamily 1, group H, member 5 S homeolog Protein, nuclear receptor subfamily 1, group H, member 4 Protein, nuclear receptor subfamily 1 group H member 4 Protein, nr1h5.S Protein, nr1h4 Protein, NR1H4 Protein, Nr1h4 Protein
- Background
- Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus
- Molecular Weight
- 70.8 kDa
- UniProt
- Q96RI1
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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