ARL2 Protein (AA 19-184, partial) (GST tag)

Catalog No. ABIN5712127

Product Details

Target: ARL2 (ADP-Ribosylation Factor-Like 2 (ARL2))

Protein Type: Recombinant

Protein Characteristics: AA 19-184, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ARL2 protein is labelled with GST tag.

Application: SDS-PAGE (SDS)

Sequence: LLMLGLDNAG KTTILKKFNG EDIDTISPTL GFNIKTLEHR GFKLNIWDVG GQKSLRSYWR NYFESTDGLI WVVDSADRQR MQDCQRELQS LLVEERLAGA TLLIFANKQD LPGALSSNAI REVLELDSIR SHHWCIQGCS AVTGENLLPG IDWLLDDISS RIFTAD

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: ARL2 (ADP-Ribosylation Factor-Like 2 (ARL2))

Alternative Name: ARL2 (ARL2 Products)

Synonyms: arfl2 Protein, MGC75676 Protein, ARFL2 Protein, 2610009M23Rik Protein, AI115441 Protein, AW553335 Protein, ADP ribosylation factor like GTPase 2 Protein, ADP-ribosylation factor-like 2 Protein, ADP-ribosylation factor like GTPase 2 Protein, arl2 Protein, ARL2 Protein, Arl2 Protein

Background: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassbly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassbly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca2+-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Molecular Weight: 46.1 kDa

UniProt: P36404

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location