c-Rel Protein (AA 3-616, partial) (His tag)

Catalog No. ABIN5713102

Product Details

Target: c-Rel (REL proto-oncogene (c-Rel))

Protein Type: Recombinant

Protein Characteristics: partial, AA 3-616

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This c-Rel protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: SGAYNPYIEI IEQPRQRGMR FRYKCEGRSA GSIPGEHSTD NNRTYPSIQI MNYYGKGKVR ITLVTKNDPY KPHPHDLVGK DCRDGYYEAE FGQERRPLFF QNLGIRCVKK KEVKEAIITR IKAGINPFNV PEKQLNDIED CDLNVVRLCF QVFLPDEHGN LTTALPPVVS NPIYDNRAPN TAELRICRVN KNCGSVRGGD EIFLLCDKVQ KDDIEVRFVL NDWEAKGIFS QADVHRQVAI VFKTPPYCKA ITEPVTVKMQ LRRPSDQEVS ESMDFRYLPD EKDTYGNKAK KQKTTLLFQK LCQDHVETGF RHVDQDGLEL LTSGDPPTLA SQSAGITVNF PERPRPGLLG SIGEGRYFKK EPNLFSHDAV VREMPTGVSS QAESYYPSPG PISSGLSHHA SMAPLPSSSW SSVAHPTPRS GNTNPLSSFS TRTLPSNSQG IPPFLRIPVG NDLNASNACI YNNADDIVGM EASSMPSADL YGISDPNMLS NCSVNMMTTS SDSMGETDNP RLLSMNLENP SCNSVLDPRD LRQLHQMSSS SMSAGANSNT TVFVSQSDAF EGSDFSCADN SMINESGPSN STNPNSHGFV QDSQYSGIGS MQNEQLSDSF PYEF

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: c-Rel (REL proto-oncogene (c-Rel))

Alternative Name: REL (c-Rel Products)

Synonyms: C-Rel Protein, c-Rel Protein, NFkB Protein, c-rel Protein, zgc:100833 Protein, Xrel2 Protein, Xrel3 Protein, rel Protein, rel-A Protein, rel2 Protein, rel3 Protein, v-rel Protein, xrel Protein, REL proto-oncogene, NF-kB subunit Protein, reticuloendotheliosis oncogene Protein, RELA proto-oncogene, NF-kB subunit Protein, v-rel avian reticuloendotheliosis viral oncogene homolog Protein, v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog Protein, ribonuclease A family member 2 pseudogene Protein, REL Protein, Rel Protein, Rela Protein, rel Protein, rel.L Protein, ECRP Protein

Background: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with mbers of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

Molecular Weight: 72 kDa

UniProt: Q04864