LZTFL1 Protein (AA 1-299) (His tag)

Catalog No. ABIN5778238

Product Details

Target: LZTFL1 (Leucine Zipper Transcription Factor-Like 1 (LZTFL1))

Protein Type: Recombinant

Protein Characteristics: AA 1-299

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This LZTFL1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVED TFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEF EKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEK ALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMA EKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED

Purity: > 90 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In PBS buffer (  pH 7.4) containing 10 % glycerol, 1  mM DTT

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: LZTFL1 (Leucine Zipper Transcription Factor-Like 1 (LZTFL1))

Alternative Name: LZTFL1 (LZTFL1 Products)

Synonyms: lztfl1 Protein, MGC53120 Protein, LZTFL1 Protein, DKFZp469B0113 Protein, fb53f12 Protein, wu:fb53f12 Protein, zgc:56268 Protein, BBS17 Protein, 5530402H04Rik Protein, 6130400H19Rik Protein, AI414725 Protein, AW048545 Protein, leucine zipper transcription factor like 1 L homeolog Protein, leucine zipper transcription factor like 1 Protein, leucine zipper transcription factor-like 1 Protein, lztfl1.L Protein, LZTFL1 Protein, lztfl1 Protein, Lztfl1 Protein

Background: LZTFL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome, a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. LZTFL1 may also function as a tumor suppressor, possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Recombinant human LZTFL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 37.0kDa (322aa) confirmed by MALDI-TOF

NCBI Accession: NP_065080

UniProt: Q9NQ48