OBFC2A Protein (AA 1-204) (His tag)
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- Target See all OBFC2A Proteins
- OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-204
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This OBFC2A protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKV ADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNP DYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product OBFC2A Protein
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Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A) (AA 1-204) protein (GST tag)
OBFC2A Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A) (AA 1-204) protein (Strep Tag)Crystallography grade OBFC2A Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A) (AA 1-198) protein (Strep Tag)Crystallography grade OBFC2A Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A) (AA 1-204), (full length) protein (His-SUMO Tag)OBFC2A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.2M NaCl, 50 % glycerol, 2 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- OBFC2A (Oligonucleotide/oligosaccharide-Binding Fold Containing 2A (OBFC2A))
- Alternative Name
- NABP1 (OBFC2A Products)
- Synonyms
- OBFC2A Protein, SOSS-B2 Protein, SSB2 Protein, 4930434H03Rik Protein, 4930442A21Rik Protein, 4930488J04Rik Protein, 4933440J18Rik Protein, 5830411E10Rik Protein, AI852561 Protein, Nbp1 Protein, Obfc2a Protein, Ssb2 Protein, RGD1306658 Protein, nucleic acid binding protein 1 Protein, NABP1 Protein, Nabp1 Protein
- Background
- Nucleic acid binding protein 1, also known as NABP1, is component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, the protein acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. This protein is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Recombinant human NABP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 24.8 kDa (227aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_001026886
- UniProt
- Q96AH0
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