TMEFF1 Protein (AA 40-330) (His tag)

Catalog No. ABIN5852926

Product Details

Target: TMEFF1 (Transmembrane Protein with EGF-Like and Two Follistatin-Like Domains 1 (TMEFF1))

Protein Type: Recombinant

Protein Characteristics: AA 40-330

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TMEFF1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSSNQPPGG GGGSGGDCPG GKGKSINCSE LNVRESDVRV CDESSCKYGG VCKEDGDGLK CACQFQCHTN YIPVCGSNGD TYQNECFLRR AACKHQKEIT VIARGPCYSD NGSGSGEGEE EGSGAEVHRK HSKCGPCKYK AECDEDAENV GCVCNIDCSG YSFNPVCASD GSSYNNPCFV REASCIKQEQ IDIRHLGHCT DTDDTSLLGK KDDGLQYRPD VKDASDQRED VYIGNHMPCP ENLNGYCIHG KCEFIYSTQK ASCRCESGYT GQHCEKTDFS ILYVVPSRQK LTHV

Purity: > 90 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.1M NaCl, 10 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: TMEFF1 (Transmembrane Protein with EGF-Like and Two Follistatin-Like Domains 1 (TMEFF1))

Alternative Name: TMEFF1 (TMEFF1 Products)

Synonyms: A830033E11 Protein, M7365 Protein, Tr1 Protein, C9orf2 Protein, CT120.1 Protein, H7365 Protein, TR-1 Protein, tomoregulin-1 Protein, fb53c10 Protein, tmeff1 Protein, wu:fb53c10 Protein, zgc:110069 Protein, transmembrane protein with EGF-like and two follistatin-like domains 1 Protein, transmembrane protein with EGF like and two follistatin like domains 1 Protein, myb/SANT-like DNA-binding domain-containing protein 3 Protein, transmembrane protein with EGF like and two follistatin like domains 1 S homeolog Protein, transmembrane protein with EGF-like and two follistatin-like domains 1b Protein, Tmeff1 Protein, TMEFF1 Protein, LOC612942 Protein, tmeff1.S Protein, tmeff1b Protein

Background: TMEFF1, also known as tomoregulin-1, is a type I transmembrane glycoprotein. This protein contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain of TMEFF1 can be released as a soluble protein. TMEFF1 is predominantly expressed in brain, but is downregulated in brain neoplasms. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto. Recombinant human TMEFF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 33.9 kDa (314aa) confirmed by MALDI-TOF

NCBI Accession: NP_003683

UniProt: Q8IYR6