CCM2 Protein (AA 66-353) (His tag)
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- Target See all CCM2 Proteins
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 66-353
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CCM2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSEVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAV LSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPES VDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQ HFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product CCM2 Protein
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Cerebral Cavernous Malformation 2 (CCM2) (AA 66-353) protein (His tag)
CCM2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Cerebral Cavernous Malformation 2 (CCM2) (AA 2-100) protein (GST tag)CCM2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Cerebral Cavernous Malformation 2 (CCM2) (AA 1-444) protein (GST tag)CCM2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Cerebral Cavernous Malformation 2 (CCM2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CCM2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. 20 mM Tris-HCl buffer ( pH 8.0) containing 20 % glycerol, 1 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- Alternative Name
- CCM2 (CCM2 Products)
- Synonyms
- C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein
- Background
- CCM2 provides instructions for making a protein called malcavernin, which strengthens the interactions between cells that form blood vessels and limits leakage from the vessels. It interacts with a number of other proteins to form a complex that is found in the junctions that connect neighboring cells. It helps turn off (suppress) a signaling molecule known as RhoA-GTPase. Recombinant human CCM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
- Molecular Weight
- 34.3kDa (311aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_001161407
- UniProt
- Q9BSQ5
- Pathways
- Cell-Cell Junction Organization
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