Bestrophin 1 Protein (BEST1) (AA 292-585) (His tag)
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- Target See all Bestrophin 1 (BEST1) Proteins
- Bestrophin 1 (BEST1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 292-585
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Bestrophin 1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSEQLINPF GEDDDDFETN WIVDRNLQVS LLAVDEMHQD LPRMEPDMYW NKPEPQPPYT AASAQFRRAS FMGSTFNISL NKEEMEFQPN QEDEEDAHAG IIGRFLGLQS HDHHPPRANS RTKLLWPKRE SLLHEGLPKN HKAAKQNVRG QEDNKAWKLK AVDAFKSAPL YQRPGYYSAP QTPLSPTPMF FPLEPSAPSK LHSVTGIDTK DKSLKTVSSG AKKSFELLSE SDGALMEHPE VSQVRRKTVE FNLTDMPEIP ENHLKEPLEQ SPTNIHTTLK DHMDPYWALE NRDEAHS
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product BEST1 Protein
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Bestrophin 1 (BEST1) (AA 1-604) protein (GST tag)
BEST1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bestrophin 1 (BEST1) (AA 361-460) protein (GST tag)BEST1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bestrophin 1 (BEST1) (AA 292-585) protein (His tag)Crystallography grade BEST1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Bestrophin 1 (BEST1) (AA 292-551) protein (His tag)Crystallography grade BEST1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Bestrophin 1 (BEST1) (AA 1-585) protein (Strep Tag)Crystallography grade BEST1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Bestrophin 1 (BEST1) (AA 1-551) protein (Strep Tag)Crystallography grade BEST1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Bestrophin 1 (BEST1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)BEST1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- Bestrophin 1 (BEST1)
- Alternative Name
- BEST1 (BEST1 Products)
- Synonyms
- CG6264 Protein, Dbest Protein, Dmel\\CG6264 Protein, anon-WO0118547.380 Protein, best Protein, dBest1 Protein, dbest1 Protein, dmBest1 Protein, BEST1 Protein, VMD2 Protein, best-1 Protein, ARB Protein, BEST Protein, BMD Protein, RP50 Protein, TU15B Protein, Bmd Protein, Vmd2 Protein, mBest1 Protein, Bestrophin 1 Protein, bestrophin 1 Protein, Best1 Protein, BEST1 Protein, best1 Protein, Bm1_25500 Protein
- Background
- BEST1 is a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Recombinant human BEST1 protein, fused to His-tag at N-terminus, was expressed in E.coli
- Molecular Weight
- 36 kDa (317aa)
- NCBI Accession
- NP_004174
- UniProt
- O76090
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