Bestrophin 1 Protein (BEST1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all Bestrophin 1 (BEST1) Proteins
- Bestrophin 1 (BEST1)
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Bestrophin 1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Bestrophin-1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product BEST1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- Bestrophin 1 (BEST1)
- Alternative Name
- Bestrophin-1 (BEST1 Products)
- Synonyms
- CG6264 Protein, Dbest Protein, Dmel\\CG6264 Protein, anon-WO0118547.380 Protein, best Protein, dBest1 Protein, dbest1 Protein, dmBest1 Protein, BEST1 Protein, VMD2 Protein, best-1 Protein, ARB Protein, BEST Protein, BMD Protein, RP50 Protein, TU15B Protein, Bmd Protein, Vmd2 Protein, mBest1 Protein, Bestrophin 1 Protein, bestrophin 1 Protein, Best1 Protein, BEST1 Protein, best1 Protein, Bm1_25500 Protein
- Background
- This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008].
- Molecular Weight
- 67.5 kDa
- NCBI Accession
- NP_004174
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