SVIP Protein (AA 1-77) (His tag)

Catalog No. ABIN5853642

Product Details

Target: SVIP (Small VCP/p97-Interacting Protein (SVIP))

Protein Type: Recombinant

Protein Characteristics: AA 1-77

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SVIP protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGLCFPC PGESAPPTPD LEEKRAKLAE AAERRQKEAA SRGILDVQSV QEKRKKKEKI EKQIATSGPP PEGGLRWTVS

Purity: > 85 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 20 % glycerol, 2  mM DTT

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: SVIP (Small VCP/p97-Interacting Protein (SVIP))

Alternative Name: SVIP (SVIP Products)

Synonyms: 1700006C13Rik Protein, 6620401M08Rik Protein, RGD1565432 Protein, small VCP interacting protein Protein, small VCP/p97-interacting protein Protein, SVIP Protein, Svip Protein

Background: Small VCP/p97-interacting protein, also known as SVIP, is involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. SVIP functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Overexpression of SVIP, on the other hand, increased the levels of p62 protein and enhanced starvation-activated autophagy as well as promoted sequestration of polyubiquitinated proteins and p62 in autophagosomes. Recombinant human SVIP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 10.8kDa (100aa) confirmed by MALDI-TOF

NCBI Accession: NP_683691

UniProt: Q8NHG7