PRKACB Protein (AA 1-398) (His tag)
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- Target See all PRKACB Proteins
- PRKACB (Protein Kinase, CAMP Dependent, Catalytic, beta (PRKACB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-398
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PRKACB protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMAAYREP PCNQYTGTTT ALQKLEGFAS RLFHRHSKGT AHDQKTALEN DSLHFSEHTA LWDRSMKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F
- Purity
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product PRKACB Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- PRKACB (Protein Kinase, CAMP Dependent, Catalytic, beta (PRKACB))
- Alternative Name
- PRKACB (PRKACB Products)
- Synonyms
- PKACB Protein, XPKAbeta Protein, kin-1 Protein, pkacb Protein, prkacba Protein, PRKACB Protein, prkacb Protein, wu:fz54b03 Protein, zgc:110804 Protein, Pkacb Protein, protein kinase cAMP-activated catalytic subunit beta Protein, protein kinase cAMP-activated catalytic subunit beta S homeolog Protein, protein kinase, cAMP-dependent, catalytic, beta Protein, protein kinase, cAMP-dependent, catalytic, beta b Protein, protein kinase, cAMP dependent, catalytic, beta Protein, PRKACB Protein, prkacb.S Protein, prkacb Protein, Prkacb Protein, prkacbb Protein
- Background
- PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. Recombinant human PRKACB protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 48.6 kDa (421aa)
- NCBI Accession
- NP_891993
- UniProt
- P22694
- Pathways
- AMPK Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Lipid Metabolism
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