ZCCHC12 Protein (AA 1-402) (His tag)

Catalog No. ABIN5853735

Product Details

Target: ZCCHC12 (Zinc Finger, CCHC Domain Containing 12 (ZCCHC12))

Protein Type: Recombinant

Protein Characteristics: AA 1-402

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ZCCHC12 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL

Purity: > 85 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: ZCCHC12 (Zinc Finger, CCHC Domain Containing 12 (ZCCHC12))

Alternative Name: ZCCHC12 (ZCCHC12 Products)

Synonyms: PNMA7A Protein, SIZN Protein, SIZN1 Protein, 2810028A01Rik Protein, AV136720 Protein, Sizn1 Protein, zinc finger CCHC-type containing 12 Protein, sterile alpha motif domain containing 12 Protein, zinc finger, CCHC domain containing 12 Protein, ZCCHC12 Protein, samd12 Protein, Zcchc12 Protein

Background: ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein , fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 47.8kDa (425aa)

NCBI Accession: NP_776159

UniProt: Q6PEW1