BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) protein (His tag)
-
- Target See all BRISC and BRCA1 A Complex Member 1 (BABAM1) Proteins
- BRISC and BRCA1 A Complex Member 1 (BABAM1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-329
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- His tag
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMEVAEPS SPTEEEEEEE EHSAEPRPRT RSNPEGAEDR AVGAQASVGS RSEGEGEAAS ADDGSLNTSG AGPKSWQVPP PAPEVQIRTP RVNCPEKVII CLDLSEEMSL PKLESFNGSK TNALNVSQKM IEMFVRTKHK IDKSHEFALV VVNDDTAWLS GLTSDPRELC SCLYDLETAS CSTFNLEGLF SLIQQKTELP VTENVQTIPP PYVVRTILVY SRPPCQPQFS LTEPMKKMFQ CPYFFFDVVY IHNGTEEKEE EMSWKDMFAF MGSLDTKGTS YKYEVALAGP ALELHNCMAK LLAHPLQRPC QSHASYSLLE EEDEAIEVEA TV
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product BABAM1 Protein
-
BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) protein (His tag)
BABAM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) protein (GST tag)BABAM1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
BRISC and BRCA1 A Complex Member 1 (BABAM1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)BABAM1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
BRISC and BRCA1 A Complex Member 1 (BABAM1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)BABAM1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol, 0.1M NaCl
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
-
- Target
- BRISC and BRCA1 A Complex Member 1 (BABAM1)
- Alternative Name
- BABAM1 (BABAM1 Products)
- Synonyms
- merit40 Protein, nba1 Protein, zgc:100909 Protein, c19orf62 Protein, C19orf62 Protein, MERIT40 Protein, NBA1 Protein, C7H19orf62 Protein, 5430437P03Rik Protein, Merit40 Protein, BRISC and BRCA1 A complex member 1 Protein, BRISC and BRCA1 A complex member 1 L homeolog Protein, babam1 Protein, BABAM1 Protein, babam1.L Protein, Babam1 Protein
- Background
- BABAM1 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Recombinant human BABAM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
- Molecular Weight
- 38.9 kDa(352aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_001028721
- UniProt
- Q9NWV8
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
-
