PDE6H Protein (AA 1-83) (His tag)
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- Target See all PDE6H Proteins
- PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-83
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PDE6H protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFG DDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII
- Purity
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product PDE6H Protein
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phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) (AA 1-83) protein (His tag)
PDE6H Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) (AA 1-83) protein (GST tag)PDE6H Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) protein (Myc-DYKDDDDK Tag)PDE6H Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.2M NaCl, 40 % glycerol, 2 mM DTT, 0.1 mM PMSF
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))
- Alternative Name
- PDE6H (PDE6H Products)
- Synonyms
- ACHM6 Protein, RCD3 Protein, A930033D18Rik Protein, PDEgamma Protein, Pde6g Protein, phosphodiesterase 6H Protein, phosphodiesterase 6H, cGMP-specific, cone, gamma Protein, PDE6H Protein, Pde6h Protein
- Background
- PDE6H is the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). Recombinant human PDE6H protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 11.5 kDa (106aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_006196
- UniProt
- Q13956
- Pathways
- EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
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