ING1 Protein (AA 1-279) (His tag)

Catalog No. ABIN5853981

Product Details

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Protein Type: Recombinant

Protein Characteristics: AA 1-279

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ING1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMLSPANG EQLHLVNYVE DYLDSIESLP FDLQRNVSLM REIDAKYQEI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY NR

Purity: > 90 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Alternative Name: ING1 (ING1 Products)

Synonyms: p24ING1c Protein, p33 Protein, p33ING1 Protein, p33ING1b Protein, p47 Protein, p47ING1a Protein, p33ING1c Protein, zgc:136918 Protein, ING1 Protein, 2610028J21Rik Protein, AA407184 Protein, AI875420 Protein, mING1h Protein, p33Ing1 Protein, p37Ing1b Protein, xing1 Protein, inhibitor of growth family member 1 Protein, inhibitor of growth family, member 1 Protein, inhibitor of growth family member 1 S homeolog Protein, ING1 Protein, Ing1 Protein, ing1 Protein, ing1.S Protein

Background: ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. This protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. Recombinant human ING1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 34.3 kDa (302aa)

NCBI Accession: NP_937862

UniProt: Q9UK53

Pathways: Protein targeting to Nucleus, Autophagy