PEBP1 Protein (AA 1-187) (His tag)

Catalog No. ABIN5854348

Product Details

Target: PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))

Protein Type: Recombinant

Protein Characteristics: AA 1-187

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PEBP1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAADISQ WAGPLCLQEV DEPPQHALRV DYAGVTVDEL GKVLTPTQVM NRPSSISWDG LDPGKLYTLV LTDPDAPSRK DPKFREWHHF LVVNMKGNDI SSGTVLSDYV GSGPPSGTGL HRYVWLVYEQ EQPLSCDEPI LSNKSGDNRG KFKVETFRKK YNLGAPVAGT CYQAEWDDYV PKLYEQLSGK

Purity: > 95 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))

Alternative Name: Pebp1 (PEBP1 Products)

Synonyms: HCNP Protein, HCNPpp Protein, PBP Protein, PEBP Protein, PEBP-1 Protein, RKIP Protein, pbp Protein, hcnp Protein, pebp Protein, rkip Protein, Pbp Protein, Pbp1 Protein, Pbpr Protein, Rkip Protein, PEBP1 Protein, BcDNA:LP12095 Protein, CG18594 Protein, Dmel\\CG18594 Protein, T2 Protein, zgc:56033 Protein, zgc:76942 Protein, phosphatidylethanolamine binding protein 1 Protein, phosphatidylethanolamine binding protein 1 L homeolog Protein, phosphatidylethanolamine-binding protein Protein, phosphatidylethanolamine-binding protein,putative Protein, Phosphatidylethanolamine-binding protein 1 Protein, PEBP1 Protein, pebp1 Protein, Pebp1 Protein, pebp1.L Protein, RR_RS07785 Protein, PVX_235290 Protein, PVX_123630 Protein, PKH_143640 Protein, EAM_1207 Protein

Background: Pebp1 also known as Phosphatidylethanolamine-binding protein 1. The protein Binds with ATP, opioids and phosphatidylethanolamine. Pebp1 exerts inhibitory activity against several serine proteases including thrombin, neuropsin, and chymotrypsin, it also inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Also, targeting Pebp1 levels can delay photoreceptor degeneration, assisting in extending the time-window for treating such rapidly progressing blindness disorder. Recombinant mouse Pebp1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 23.2kDa (210aa) confirmed by MALDI-TOF

NCBI Accession: NP_061346

UniProt: P70296

Pathways: Feeding Behaviour