LILRA6 Protein (AA 24-447) (His tag,AVI tag,Biotin)

Catalog No. ABIN5955019

Product Details

Target: LILRA6 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 (LILRA6))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 24-447

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LILRA6 protein is labelled with His tag,AVI tag,Biotin.

Sequence: AA 24-447

Specificity: Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Comment:

Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: LILRA6 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 (LILRA6))

Alternative Name: LILRA6 (LILRA6 Products)

Synonyms: CD85b Protein, ILT-8 Protein, ILT5 Protein, ILT8 Protein, LILRB3 Protein, LILRB6 Protein, LIRe Protein, leukocyte immunoglobulin like receptor A6 Protein, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 Protein, LILRA6 Protein

Background: The LILRs are a family of receptors that regulate the activities of myelomonocytic cells. LILRB3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 (ILT5) and LILRA6 (ILT8) are highly polymorphic receptors with similar extracellular domains. LILRA6 can signal through association with an activating adaptor molecule, FcRγ, which bears a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif. Analysis of mRNA expression in the major fractions of PBMCs showed that LILRA6 is primarily expressed in monocytes, and its expression level correlates with copy number of the gene.

Molecular Weight: 50.0 kDa