CCL17 Protein
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- Target See all CCL17 Proteins
- CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))
- Protein Type
- Recombinant
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Origin
- Human
- Host
- Please inquire
- Sequence
- ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S.
- Characteristics
- Recombinant Human Thymus and Activation Regulated Chemokine (TARC) / CCL17
- Purity
- > 97.0 % as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
- Top Product
- Discover our top product CCL17 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- The protein was lyophilized from a concentrated (0.5mg/ml) solution containing 20mM PBS and 150mM NaCl pH-7.4.It is recommended to reconstitute the lyophilized CCL17 in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
- Storage
- -20 °C
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Altered profile of chemokines in fibromyalgia patients." in: Annals of clinical biochemistry, Vol. 51, Issue Pt 5, pp. 576-81, (2014) (PubMed).
: "
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Altered profile of chemokines in fibromyalgia patients." in: Annals of clinical biochemistry, Vol. 51, Issue Pt 5, pp. 576-81, (2014) (PubMed).
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- Target
- CCL17 (Chemokine (C-C Motif) Ligand 17 (CCL17))
- Alternative Name
- Thymus and Activation Regulated Chemokine (TARC) / CCL17 (CCL17 Products)
- Synonyms
- A-152E5.3 Protein, ABCD-2 Protein, SCYA17 Protein, TARC Protein, CCL17 Protein, Abcd-2 Protein, Scya17 Protein, Scya17l Protein, Tarc Protein, abcd2 Protein, C-C motif chemokine ligand 17 Protein, chemokine (C-C motif) ligand 17 Protein, ATP-binding cassette sub-family D member 2 Protein, CCL17 Protein, Ccl17 Protein, LOC100537809 Protein
- Background
- CCL17 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa. The TARC is purified by proprietary chromatographic techniques. Introduction: TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1alpha, MIP-1beta, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. Synonyms: C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.
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