PDCD1LG2 Protein (AA 20-219) (Fc Tag)
-
- Target See all PDCD1LG2 Proteins
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-219
-
Origin
- Human
-
Source
- CHO Cells
- Purification tag / Conjugate
- This PDCD1LG2 protein is labelled with Fc Tag.
- Purpose
- CD273 [PD-L2] (human):Fc (mouse) (rec.)
- Specificity
- The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Characteristics
- Protein. The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1, CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product PDCD1LG2 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
-
- Target
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
- Alternative Name
- CD273 [PD-L2] (PDCD1LG2 Products)
- Synonyms
- PDL2 Protein, B7DC Protein, Btdc Protein, CD273 Protein, PD-L2 Protein, PDCD1L2 Protein, bA574F11.2 Protein, B7-DC Protein, F730015O22Rik Protein, programmed cell death 1 ligand 2 Protein, PDCD1LG2 Protein, Pdcd1lg2 Protein
- Background
-
Alternate Names/Synonyms: Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-DC, PDL2
Product Description: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1, CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
- NCBI Accession
- NP_079515
-