TIMD4 Protein (AA 25-315) (Fc Tag)
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- Target See all TIMD4 Proteins
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-315
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TIMD4 protein is labelled with Fc Tag.
- Purpose
- Tim-4 (human):Fc (mouse) (rec.)
- Specificity
- The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Characteristics
- Protein. The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <5EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
- Top Product
- Discover our top product TIMD4 Protein
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T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)
TIMD4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-305) protein (His tag)TIMD4 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) protein (His tag)TIMD4 Origin: Mouse Host: HEK-293 Cells Recombinant > 94 % as determined by SDS-PAGE
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)Crystallography grade TIMD4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-279) protein (His tag)Crystallography grade TIMD4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-378) protein (rho-1D4 tag)Crystallography grade TIMD4 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-343) protein (rho-1D4 tag)Crystallography grade TIMD4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- Alternative Name
- Tim-4 (TIMD4 Products)
- Synonyms
- RGD1564516 Protein, MGC99322 Protein, TIMD4 Protein, B430010N18Rik Protein, TIM-4 Protein, Tim4 Protein, SMUCKLER Protein, TIM4 Protein, T-cell immunoglobulin and mucin domain containing 4 Protein, T-cell immunoglobulin and mucin domain containing 4 L homeolog Protein, T cell immunoglobulin and mucin domain containing 4 Protein, Timd4 Protein, TIMD4 Protein, timd4.L Protein
- Background
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Alternate Names/Synonyms: TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
- Molecular Weight
- ~80kDa (SDS-PAGE)
- NCBI Accession
- NP_612388
- Pathways
- Cancer Immune Checkpoints
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