TNFRSF4 Protein (AA 50-183) (Fc Tag)
-
- Target See all TNFRSF4 Proteins
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 50-183
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF4 protein is labelled with Fc Tag.
- Purpose
- Fc (human):OX40L, Soluble (human) (rec.)
- Specificity
- The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1.
- Characteristics
- Protein. The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/μg purified protein (LAL test, Lonza). Lyophilized. Contains PBS. Purity: >95 % (SDS-PAGE). OX40L [CD252, TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Biological Activity Comment
- Activates T cell proliferation.
- Top Product
- Discover our top product TNFRSF4 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
-
- Target
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- Alternative Name
- OX40L, Soluble (TNFRSF4 Products)
- Synonyms
- TNFRSF4 Protein, ACT35 Protein, CD134 Protein, Ly-70 Protein, Ox40 Protein, TXGP1L Protein, Txgp1 Protein, OX40 Protein, TNF receptor superfamily member 4 Protein, tumor necrosis factor receptor superfamily, member 4 Protein, TNFRSF4 Protein, Tnfrsf4 Protein
- Background
-
Alternate Names/Synonyms: CD252, CD134L, OX40 Ligand, TNFSF4, Tumor Necrosis Factor Superfamily Member 4, TAX Transcriptionally-activated Glycoprotein 1, TXGP1, Gp34
Product Description: OX40L [CD252, TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.
- UniProt
- P23510
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
-