TMED10 Protein (AA 32-185) (His tag)

Catalog No. ABIN6387259

Product Details

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Protein Type: Recombinant

Protein Characteristics: AA 32-185

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TMED10 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR

Purity: > 85 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 30 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Alternative Name: TMED10 (TMED10 Products)

Synonyms: tmp21 Protein, P24(DELTA) Protein, S31I125 Protein, S31III125 Protein, TMP21 Protein, Tmp-21-I Protein, p23 Protein, 1110014C03Rik Protein, Tmp21 Protein, p24delta1 Protein, fe06g04 Protein, wu:fb98e10 Protein, wu:fe06g04 Protein, zgc:85681 Protein, transmembrane p24 trafficking protein 10 L homeolog Protein, transmembrane p24 trafficking protein 10 Protein, tmed10.L Protein, TMED10 Protein, Tmed10 Protein, tmed10 Protein

Background: TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. Recombinant human TMED10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molecular Weight: 20 kDa (177aa), confirmed by MALDI-TOF

NCBI Accession: NP_006818

UniProt: P49755