TMED10 Protein (AA 32-185) (His tag)
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- Target See all TMED10 Proteins
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 32-185
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TMED10 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product TMED10 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 30 % glycerol.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
- Alternative Name
- TMED10 (TMED10 Products)
- Synonyms
- tmp21 Protein, P24(DELTA) Protein, S31I125 Protein, S31III125 Protein, TMP21 Protein, Tmp-21-I Protein, p23 Protein, 1110014C03Rik Protein, Tmp21 Protein, p24delta1 Protein, fe06g04 Protein, wu:fb98e10 Protein, wu:fe06g04 Protein, zgc:85681 Protein, transmembrane p24 trafficking protein 10 L homeolog Protein, transmembrane p24 trafficking protein 10 Protein, tmed10.L Protein, TMED10 Protein, Tmed10 Protein, tmed10 Protein
- Background
- TMED10 is a member of the EMP24/GP25L/p24 family and a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. Recombinant human TMED10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 20 kDa (177aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_006818
- UniProt
- P49755
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