Growth Hormone Receptor Protein (GHR) (AA 19-264) (Fc Tag)

Catalog No. ABIN6809923

Recombinant Growth Hormone Receptor protein expressed in HEK-293 Cells.

Quick Overview for Growth Hormone Receptor Protein (GHR) (AA 19-264) (Fc Tag) (ABIN6809923)

Target: Growth Hormone Receptor (GHR)

Protein Type: Recombinant

Biological Activity: Active

Origin: Rhesus Monkey

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 19-264

Purification tag / Conjugate: This Growth Hormone Receptor protein is labelled with Fc Tag.

Sequence: AA 19-264

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: Growth Hormone Receptor (GHR)

Alternative Name: Growth Hormone R

Background: Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Molecular Weight: 54.7 kDa

NCBI Accession: NP_001036132

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus