tau Protein (full length, Pro301Ser-Mutant)
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- Target See all tau Proteins
- tau (tau Protein)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Pro301Ser-Mutant, full length
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
- Purpose
- Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils
- Sequence
- MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV SGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Specificity
- ~45.8 kDa
- Purification
- Ion-exchange Purified
- Biological Activity Comment
- Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
- Top Product
- Discover our top product tau Protein
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tau Protein (partial), (Pro301Leu-Mutant) (Active) protein
Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active
tau Protein (AA 241-380) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
tau Protein (AA 200-380) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
tau Protein (AA 1-383) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
tau Protein (AA 1-352) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
tau Protein (AA 1-381) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
tau Protein (AA 1-412) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % by SDS - PAGE SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Buffer
- 10 mM HEPES, 100 mM NaCl pH 7.4
- Storage
- -80 °C
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- Target
- tau (tau Protein)
- Alternative Name
- Tau (tau Products)
- Synonyms
- DDPAC Protein, FTDP-17 Protein, MAPTL Protein, MSTD Protein, MTBT1 Protein, MTBT2 Protein, PPND Protein, TAU Protein, tau Protein, PHF-tau Protein, microtubule associated protein tau Protein, MAPT Protein
- Background
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
- NCBI Accession
- NP_005901
- UniProt
- P10636
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