Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag)

Catalog No. ABIN6938865

Product Details

Target: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Protein Type: Recombinant

Protein Characteristics: AA 39-426

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: His tag

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 40 mM HEPES, 120 mM NaCl, pH 7.5

Storage: -20 °C

Target Details

Target: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Alternative Name: CBLB (CBLB Products)

Synonyms: rnf56 Protein, cblb Protein, AI429560 Protein, AI851073 Protein, Cbl-b Protein, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog Protein, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog Protein, Casitas B-lineage lymphoma b Protein, Cbl proto-oncogene B Protein, cblb.S Protein, cblb.L Protein, Cblb Protein, CBLB Protein

Background: Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

Molecular Weight: 47.0 kDa

NCBI Accession: NP_733762