ACE2 Protein (His tag)
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- Target See all ACE2 Proteins
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Protein Type
- Recombinant
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Origin
- Paguma larvata
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ACE2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purpose
- Paguma larvata ACE2 / ACEH Protein, His Tag
- Sequence
- AA 18-740
- Characteristics
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Paguma larvata ACE2, His Tag (AC2-P5248) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Thr 740 (Accession # Q56NL1-1). Predicted N-terminus: His
This protein carries a polyhistidine tag at the N-terminus. - Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ACE2 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -80 °C
- Storage Comment
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The product MUST be stored at -70°C or lower upon receipt
-70°C for 3 months under sterile conditions.
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- Target
- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
- Alternative Name
- ACE2 (ACE2 Products)
- Synonyms
- ACE1 Protein, CD143 Protein, DCP Protein, DCP1 Protein, ICH Protein, MVCD3 Protein, ACEH Protein, 2010305L05Rik Protein, zgc:92514 Protein, angiotensin I converting enzyme Protein, angiotensin I converting enzyme 2 Protein, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Protein, ACE Protein, ACE2 Protein, Ace2 Protein, ace2 Protein
- Background
- Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
- Molecular Weight
- 85.7 kDa
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
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