Claudin 6 Protein (CLDN6) (AA 1-4) (mFc Tag)

Catalog No. ABIN6961123

Product Details

Target: Claudin 6 (CLDN6)

Protein Type: Recombinant

Protein Characteristics: AA 1-4

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Claudin 6 protein is labelled with mFc Tag.

Purpose: Recombinant human CLDN6 Protein with C-terminal mouse Fc Tag

Specificity: CLDN6 (Met1-Ala4) (Gln57-Gln78) (Arg145-Arg158) mFc (Pro99-Lys330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Claudin 6 (CLDN6)

Alternative Name: CLDN6 (CLDN6 Products)

Synonyms: cldn4l2 Protein, cldn6 Protein, CLDN6 Protein, AL024037 Protein, claudin 6, gene 1 L homeolog Protein, claudin 6 Protein, cldn6.1.L Protein, CLDN6 Protein, Cldn6 Protein

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Molecular Weight: predicted molecular mass of 31.6 kDa after removal of the signal peptide.

Gene ID: 9074

UniProt: P56747

Pathways: Hepatitis C