CD3D Protein (His tag)

Catalog No. ABIN6964120

Product Details

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CD3D protein is labelled with His tag.

Purpose: Recombinant human CD3D protein with C-terminal 6xHis tag

Specificity: CD3D (Phe22-Ala105) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Alternative Name: CD3D (CD3D Products)

Synonyms: CD3-DELTA Protein, T3D Protein, CD3 Protein, T3d Protein, CD3d molecule Protein, CD3 antigen, delta polypeptide Protein, CD3D Protein, Cd3d Protein

Background: Synonymes: CD3D,CD3-DELTA,T3D
Description: The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

Molecular Weight: predicted molecular mass of 10.4 kDa after removal of the signal peptide. The apparent molecular mass of CD3D-His is 15-25 kDa due to glycosylation.

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events