CD13 Protein (His tag)

Catalog No. ABIN7042539

Product Details

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CD13 protein is labelled with His tag.

Purpose: Recombinant human ANPEP protein with C-terminal 6xHis tag

Specificity: ANPEP (Lys69-Lys967) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Alternative Name: ANPEP (ANPEP Products)

Synonyms: APN Protein, CD13 Protein, GP150 Protein, LAP1 Protein, P150 Protein, PEPN Protein, A2AP Protein, AAP Protein, ALPHA-2-PI Protein, API Protein, PLI Protein, AAT1 Protein, ALT1 Protein, GPT1 Protein, Gpt1 Protein, Apn Protein, pepN Protein, SC8E4A.13 Protein, 1300007J06Rik Protein, 2310022B03Rik Protein, ALT Protein, Gpt-1 Protein, AP-M Protein, AP-N Protein, Cd13 Protein, Apm Protein, KZP Protein, Lap1 Protein, rAPN Protein, APDE Protein, p150 Protein, anpep Protein, fb64c05 Protein, wu:fb64c05 Protein, zgc:136771 Protein, alanyl aminopeptidase, membrane Protein, serpin family F member 2 Protein, glutamic--pyruvic transaminase Protein, aminopeptidase N Protein, aminopeptidase Protein, aminopeptidase n Protein, glutamic pyruvic transaminase, soluble Protein, alanyl (membrane) aminopeptidase Protein, membrane alanyl aminopeptidase Protein, alanyl (membrane) aminopeptidase b Protein, alanyl aminopeptidase, membrane L homeolog Protein, ANPEP Protein, SERPINF2 Protein, GPT Protein, Gpt Protein, Apn2 Protein, Apn1 Protein, SCO2643 Protein, pepN Protein, Shewana3_0897 Protein, Alvin_1024 Protein, Ndas_3413 Protein, Saut_1544 Protein, Fbal_1877 Protein, ML5_3424 Protein, Despr_1988 Protein, Mesop_5365 Protein, Anpep Protein, LOC101744250 Protein, anpepb Protein, anpep.L Protein

Background: Synonymes: APN, CD13, GP150, LAP1, P150, PEPN
Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.

Molecular Weight: predicted molecular mass of 103.6 kDa after removal of the signal peptide. The apparent molecular mass of ANPEP-His is 130-250 kDa due to glycosylation.

UniProt: P15144

Pathways: Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones