Neuregulin 1 Protein (NRG1) (Fc Tag)

Catalog No. ABIN6964402

Product Details

Target: Neuregulin 1 (NRG1)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Neuregulin 1 protein is labelled with Fc Tag.

Application: ELISA

Purpose: Recombinant human NRG1 Protein with C-terminal Human Fc tag

Specificity: NRG1 (Ser20-Arg242) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1 (NRG1 Products)

Synonyms: 6030402G23Rik Protein, ARIA Protein, D230005F13Rik Protein, GGF Protein, GGFII Protein, HRG Protein, HRGalpha Protein, Hgl Protein, NDF Protein, SMDF Protein, GGF2 Protein, HGL Protein, HRG1 Protein, HRGA Protein, MST131 Protein, NRG-1 Protein, heregulin Protein, nrg1-A Protein, pro-neuregulin-1 Protein, NRG1 Protein, wu:fm70e01 Protein, DKFZp459A1838 Protein, neuregulin 1 Protein, histidine rich glycoprotein Protein, neuregulin 1 L homeolog Protein, Nrg1 Protein, NRG1 Protein, HRG Protein, nrg1.L Protein, nrg1 Protein

Background: Synonymes: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
Description: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Molecular Weight: predicted molecular mass of 50.3 kDa after removal of the signal peptide.The apparent molecular mass of NRG1-hFc is 55-70 kDa due to glycosylation.

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation