ADAM17 Protein (Fc Tag)
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- Target See all ADAM17 Proteins
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ADAM17 protein is labelled with Fc Tag.
- Sequence
- ADAM17 (Lys215-Asn671)+hFc(GLU99-ALA330)
- Characteristics
- Tagged Protein: C-Human Fc tag
- Purification
- affinity purification
- Top Product
- Discover our top product ADAM17 Protein
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ADAM Metallopeptidase Domain 17 (ADAM17) (AA 752-824) protein (His-IF2DI Tag)
ADAM17 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) protein (GST tag)ADAM17 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 693-824) protein (His tag)Crystallography grade ADAM17 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 693-827) protein (His tag)Crystallography grade ADAM17 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-671) protein (His tag)Crystallography grade ADAM17 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-671) protein (His tag)Crystallography grade ADAM17 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-824) protein (rho-1D4 tag)Crystallography grade ADAM17 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-827) protein (rho-1D4 tag)Crystallography grade ADAM17 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with deionized water
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Preservative
- Without preservative
- Storage
- -80 °C
- Storage Comment
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
- Expiry Date
- 12 months
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- Target
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- Alternative Name
- ADAM17 (ADAM17 Products)
- Synonyms
- ADAM18 Protein, CD156B Protein, CSVP Protein, NISBD Protein, TACE Protein, CD156b Protein, Tace Protein, adam17 Protein, si:dkey-81b15.2 Protein, adam18 Protein, cd156b Protein, csvp Protein, tace Protein, fc20b01 Protein, wu:fc20b01 Protein, zgc:63886 Protein, ADAM metallopeptidase domain 17 Protein, a disintegrin and metallopeptidase domain 17 Protein, ADAM metallopeptidase domain 17b Protein, ADAM metallopeptidase domain 17 L homeolog Protein, ADAM metallopeptidase domain 17a Protein, ADAM17 Protein, Adam17 Protein, adam17b Protein, adam17.L Protein, adam17a Protein
- Background
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Synonymes: ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016] - Molecular Weight
- 75.79 kDa
- UniProt
- P78536
- Pathways
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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