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MARCO Protein (AA 79-520) (His tag)

MARCO Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Catalog No. ABIN7013011
  • Target See all MARCO Proteins
    MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 79-520
    Origin
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This MARCO protein is labelled with His tag.
    Purpose
    Human MARCO Protein, His Tag
    Purity
    >90 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product MARCO Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -20 °C
  • Target
    MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
    Alternative Name
    MARCO (MARCO Products)
    Synonyms
    AI323439 Protein, Ly112 Protein, Scara2 Protein, SCARA2 Protein, macrophage receptor with collagenous structure Protein, MARCO Protein, Marco Protein
    Background
    MARCO is also known as Scavenger receptor class A member 2 and SCARA2. Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. MARCO ligation promotes the production of inflammatory mediators by macrophages. MARCO mediated internalization of some ligands prevents their activation of cell surface TLR4 but enables their activation of intracellular TLR3. MARCO contributes to the clearance of apoptotic cells and inhaled bacteria, mast cell mediated silicosis, and the amelioration of allergen or ozone induced lung inflammation. It is required for the organization of the splenic marginal zone and the interaction of splenic macrophages and B cells.
    Molecular Weight
    45.9 kDa
    Pathways
    Activation of Innate immune Response
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