SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N) (D63G, D377Y, G215C, R203M) (His tag)

Catalog No. ABIN7013104

Product Details

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: D377Y, D63G, G215C, R203M

Origin: SARS Coronavirus-2 (SARS-CoV-2)

Source: HEK-293 Cells

Purification tag / Conjugate: This SARS-CoV-2 Nucleocapsid protein is labelled with His tag.

Purpose: SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y), His Tag

Specificity: SARS-CoV-2 Nucleocapsid protein (D63G, R203M, G215C, D377Y)

Characteristics: SARS-CoV-2 Nucleocapsid protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1). Mutations D63G, R203M, G215C, D377Y are identified in the SARS-CoV-2 Delta Variant (B.1.617.2) and sub-lineages of Delta (AY.1/AY.2/AY.3; "Delta Plus").

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.3 with 0.2 M Arginine

Storage: -20 °C

Target Details

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Alternative Name: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N Products)

Synonyms: nucleocapsid phosphoprotein Protein, N Protein

Target Type: Viral Protein

Background: Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Molecular Weight: 47.3 kDa

NCBI Accession: QHO62115