HBEGF Protein (Fc Tag)

Catalog No. ABIN7092838

Product Details

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This HBEGF protein is labelled with Fc Tag.

Purpose: Recombinant Human HBEGF with C-terminal human Fc tag

Specificity: HBEGF (Leu20-Thr160) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: affinity purification

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Alternative Name: HBEGF (HBEGF Products)

Synonyms: hbegf Protein, zgc:165443 Protein, HBEGF Protein, zgc:175091 Protein, DTR Protein, DTS Protein, DTSF Protein, HEGFL Protein, Dtr Protein, GFHB Protein, Hb-egf Protein, Hegfl Protein, AW047313 Protein, Dts Protein, HB-EGF Protein, heparin-binding EGF-like growth factor b Protein, heparin binding EGF like growth factor Protein, Heparin-binding EGF-like growth factor Protein, heparin-binding EGF-like growth factor a Protein, heparin-binding EGF-like growth factor Protein, hbegfb Protein, HBEGF Protein, hbegf Protein, hbegfa Protein, Hbegf Protein

Background: Synonymes: DTR,DTS,DTSF,HEGFL
Description: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB/Swiss-Prot Function]

Molecular Weight: predicted molecular mass of 41.9 kDa after removal of the signal peptide. The apparent molecular mass of HBEGF-hFc is 35-55 kDa due to glycosylation.

UniProt: Q99075

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway